This handbook is an up-to-date, evidence based quick, easy reference guide for expert regional anesthesia providers. It will also be an invaluable tool and a great entry point for amateurs" sonographers who wish to understand the basics of ultrasound, its uses for diagnosis and treatment, current guidelines and standards of care. It presents in details challenges, stratification of risks, techniques, and approaches to facilitate effective ultrasound use in perioperative pain control and emergency room pain management. This uses an outline, schematic approach for easy understanding and retention.