Thyroid nodules with benign signs might be subjectively diagnosed as malignant, leading to over treatment, and nodules with malignant signs might be regarded as benign causing insufficient curing. In order to improve the accuracy rate of thyroid nodules, this book analysed ultrasound diagnosis for thyroid nodules in multiple difficult and misdiagnosed cases from thyroid surgeons’ perspective and closely combined ultrasound imaging with clinical information, including ultrasound images and palpation of thyroid nodules, ultrasound detection video, gross specimen and pathologic diagnosis to interpret the ultrasound images of thyroid nodules, which can be a reference for thyroid surgeons and beginner.